Why do infants die from pertussis




















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Supplement sponsorship. Potential conflict of interest. The author has given pertussis talks for Sanofi Pasteur and consulted for GlaxoSmithKline on pertussis vaccines in Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

National Center for Biotechnology Information , U. Clin Infect Dis. Published online Nov 2. James D. Author information Copyright and License information Disclaimer. Correspondence: J. This article has been cited by other articles in PMC. Abstract In typical pertussis in young infants, the child will appear deceptively well; he or she will have coryza, sneezing, and a mild cough.

Rates of Reported Pertussis In the prevaccine era in the United States, the average yearly rate of reported pertussis was per population [ 14 ]. Deaths Due to Pertussis In the prevaccine era, deaths due to pertussis were noted in children of all ages and also in adults [ 14 , 25 ]. Source of Pertussis in Infants Studies done in the whole-cell vaccine era indicated that the source of infection in an infant was usually an adult family member with a cough illness that was not recognized as pertussis [ 14 , 15 , 21 , 26 — 28 ].

Notes Acknowledgments. References 1. Cherry JD. The history of pertussis whooping cough ; — facts, myths, and misconceptions. Curr Epidemiol Rep ; 2 — Holmes WH. Bacillary and rickettsial infections, acute and chronic: a textbook. New York: Macmillan, — Pathogenesis and histopathology of pertussis: implications for immunization. Expert Rev Vaccines ; 13 — Pertussis: challenges today and for the future.

PLoS Pathogens ; 9 :e J Pediatric Infect Dis Soc ; 2 :1—6. Bordetella pertussis and other Bordetella spp. In: Remington and Klein's infectious diseases of the fetus and newborn infant. Exchange blood transfusion in the management of severe pertussis in young infants.

Pediatric Infect Dis J ; 32 —9. Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Clin Infect Dis ; 47 — Risk factors associated with infant deaths from pertussis: a case-control study. Clin Infect Dis ; 61 — Bordet J, Genou O.

Le microbe de la coqueluche. Ann Inst Pasteur — Report of the task force on pertussis and pertussis immunization— Pediatrics ; 81 — The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection.

Pediatrics ; —7. Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev ; 18 — The epidemiology of pertussis and pertussis immunization in the United Kingdom and the United States: a comparative study.

Curr Probl Pediatrics ; 14 :1— Cherry JD, Heininger U. Pertussis and other Bordetella infections. Hospital-diagnosed pertussis infection in children and long-term risk of epilepsy. JAMA ; —9. Study of intellectual performance of children in ordinary schools after certain serious complications of whooping cough.

Clinical findings in Bordetella pertussis infections: results of a prospective multicenter surveillance study. Pediatrics ; :E Pediatrics ; :1— A search for Bordetella pertussis infection in university students. Clin Infect Dis ; 14 — Adult pertussis in the pre- and post-vaccine eras: lifelong vaccine-induced immunity?

Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J ; 24 5 suppl :S58— The recurrence of whooping cough: possible implications for assessment of vaccine efficacy. Lancet ; 1 —9. Nicoll A, Gardner A. Whooping cough and unrecognised postperinatal mortality. Pertussis is a very contagious disease caused by a bacterium that affects the lungs and airways. It spreads by coughing or sneezing.

The first symptoms of pertussis are similar to a cold: sneezing, a runny nose, possibly a slight fever, and a cough. After one or two weeks, the cough becomes more severe. The coughing fits usually last from one to six weeks, but can go on for 10 weeks or more. Health care providers should consider pertussis as a diagnosis in patients with a persistent cough illness and check vaccination history at each visit.

For more information, go to Pertussis Whooping Cough. News and Announcements News and Announcements Home news releases news releases news releases news releases news releases Resources for reporters Information Officers.

News Release January 8, Contact information MDH reports pertussis-related death of infant Health officials stress importance of vaccination, especially during pregnancy Minnesota health officials have confirmed an infant death related to pertussis, also known as whooping cough. Other things you can do to prevent the spread of pertussis are: Avoid close contact with others who are coughing or otherwise ill. Wash your hands often.



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