Where is d aspartate found

These data are in agreement with previous results obtained by other investigators [ 27 — 29 ], who demonstrated that the molecule involved in the signal transduction for other metabolites in the rat pituitary was cGMP.

Similarly, in vitro experiments conducted on isolated Leydig cells incubated in a medium containing 0. Also, this last result is in agreement with previous studies by other investigators in which it was demonstrated that the increase of testosterone synthesized by Leydig cells occurs under the intervention of the cAMP [ 30 ]. The final concern of this study was to examine the biosynthesis of D-Asp in the pituitary and testis. The results demonstrated that rat tissues contain a racemase activity that is capable of converting L-Asp into D-Asp.

We have termed this enzyme "D-aspartate racemase" and it is present in all the rat tissues we analyzed. The pituitary and the testis are the tissues with higher concentrations Fig. These data thus indicate that a relationship exists between the endogenous concentration of D-Asp and the concentration of the D-aspartate racemase in the tissues Fig. In this study, we also investigated the action of L-Asp on hormone release in rats.

A group of 10 male rats were treated with L-Asp instead of D-Asp at the same time and at the same concentration and then levels of LH and testosterone in the blood were determined. The results of this investigation indicated that the L-Asp does not induce any significant increase of serum LH or testosterone data not shown , thus indicating thus that only the stereochemical form of D-Asp is active in the hormone release.

Here we demonstrated that D-aspartic acid, which occurs as a physiological compound in the mammalian pituitary and testis, has a role in the regulation of the release and synthesis of LH and testosterone. In humans and rats, sodium D-Asp treatment enhances the release of LH and testosterone. The experiments that we carried out on rats have permitted us to understand that this amino acid regulates the synthesis of LH and testosterone in the pituitary and the testis respectively.

This action is mediated in the pituitary by cGMP and in the testis by cAMP, which act as the second messengers in the signal transduction in the pituitary and testes respectively.

The pituitary and testis possesses a D-Aspartate racemase, which provides the necessary production of D-Asp. Commercial integrator consisting of sodium D-aspartate and vitamins, produced by the 'Pharmaguida s.

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